Molecular program of human HSPCs after birth
We provided an integral transcriptomic analysis of HSPCs, defined their dynamics in postnatal steady-state hematopoiesis and refined the heterogeneity of MPPs by CD52 expression. Neonate bone marrow-derived HSCs exhibited higher reconstruction capability than cord blood HSCs. This resource will help understand hematopoiesis in development and disease. Developmental Cell. 2022.
HSPCs and T cells in Aplastic anemia
These data collectively constitute the transcriptomic landscape of disrupted hematopoiesis in AA at single-cell resolution, providing new insights into the molecular interactions of engaged T cells with residual HSPCs and render novel therapeutic opportunities for AA. Blood. 2021.
COVID-19 severity represented by blood cells
Our work uncovers the cellular and molecular players underlying the disordered and heterogeneous immune responses associated with COVID-19 severity, which could provide valuable insights for the treatment of critical COVID-19 patients. Sci China Life Sci. 2021.
Atlas of Human Blood Cells
By in-depth sequencing and analysis of 32 immunophenotype-enriched blood cells at single-cell resolution, we built the transcriptional atlas of human blood cells. National Science Review. 2020.
HSC Transplantation
We used single-cell RNA-seq to construct a comprehensive transcriptome reference in mouse homeostasis and guide the tracing of HSC transplantation dynamics in early one week window. Nature Cell Biology. 2020.
